Screen Readers Skip to Content

Use of IVF Procedure for Male Infertility Doubled

Author: The JAMA Network Journals
Published: 20th Jan 2015 - Updated: 21st Jan 2015
Peer-Reviewed Publication: N/A
Additional References: IVF, Adoption, Fertility Publications

Summary: Use of ICSI doubled between 1996 and 2012, although compared with conventional in vitro fertilization (IVF), was not associated with improved reproductive outcomes.


Main Document

The use of an assisted reproduction technique known as intracytoplasmic sperm injection (ICSI) doubled between 1996 and 2012, although compared with conventional in vitro fertilization (IVF), use of ICSI was not associated with improved reproductive outcomes, according to a study in the January 20 issue of JAMA.

Intracytoplasmic sperm injection is an IVF procedure in which a single sperm is injected directly into an egg.

The introduction of ICSI in 1992 revolutionized the treatment of couples with male factor infertility (infertility due to abnormal semen characteristics, abnormal sperm function, or surgical sterilization), and made paternity possible for a large proportion of men with no measurable sperm count. In contrast to conventional IVF, ICSI bypasses natural barriers to fertilization, thereby increasing the possibility of the transmission of genetic defects compared to conventional IVF. In addition, the procedure is also considerably more expensive than conventional IVF and adds to financial burdens already experienced by many couples undergoing fertility treatment, according to background information in the article.

Sheree L. Boulet, Dr.P.H., M.P.H., of the Centers for Disease Control and Prevention, Atlanta, and colleagues assessed national trends and reproductive outcomes of fresh IVF cycles (embryos transferred without being frozen) associated with the use of ICSI compared with conventional IVF.

The researchers used data on fresh IVF and ICSI cycles reported to the U.S. National Assisted Reproductive Technology Surveillance System during 1996-2012.

In the absence of male factor infertility, ICSI use was associated with small but statistically significant decreases in implantation, pregnancy, live birth, multiple live birth, and low birth weight rates compared with conventional IVF.

"Although such differences may be a function of the large sample size and thus not clinically relevant, our findings suggest that use of ICSI may improve fertilization rates but not implantation or pregnancy rates in the setting of unexplained infertility, advanced maternal age, and low oocyte [a cell from which an egg develops] yield," the authors write.

This study was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health. All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Post to Twitter Add to Facebook

Latest IVF, Adoption, Fertility Publications

The above information is from our reference library of resources relating to IVF, Adoption, Fertility that includes:

Dr. Geva Shenkman Lachberg - Image Credit: Adi Cohen Tzedek. thumbnail image
Study explores predictors of parents desire for more children, whether heterosexual parents want more children than same-sex parents, and if there is a difference between homosexual fathers and lesbian mothers when it comes to the desire for more children.
Publish Date: 26th Oct 2022 - Updated: 5th Jan 2023
Transgender Men Need Fertility Preservation Counseling thumbnail image.
Researchers provide guidelines for fertility preservation counseling before gender-affirming medical procedures for transgender men.
Publish Date: 6th Sep 2022 - Updated: 5th Jan 2023
Sex Survey Results for Should Same-Sex Couples be Allowed to Adopt? thumbnail image.
Results from annual sex survey, where over 1,000 adults were asked how they felt about gay and lesbian couples adopting a child.
Publish Date: 15th Feb 2018
Success rates in Same Sex Female Couples Undergoing Intrauterine Insemination with Donor Sperm thumbnail image.
RMA of NY presents findings from research study exploring fertility treatments outcomes of same-sex female couples, single women, and infertile heterosexual couples.
Publish Date: 11th Nov 2017


1How Many Genders Are There?
Alphabetical list of gender identities.

2Transgender Reporting Guide
How to write about transgender people.

3Glossary of Sexuality Terms
Definitions of sexual terms & acronyms.

4Glossary of Sexual Identities
Definitions of gender related terms.

5Am I Gay? Questions to Ask
Think you may be gay or bisexual?

• Submissions: Send us your coming events and LGBTQ related news stories.


• Report Errors: Please report outdated or inaccurate information to us.



• (APA): The JAMA Network Journals. (2015, January 20). Use of IVF Procedure for Male Infertility Doubled. SexualDiversity.org. Retrieved May 27, 2024 from www.sexualdiversity.org/news/same/ivf/343.php


• Permalink: <a href="https://www.sexualdiversity.org/news/same/ivf/343.php">Use of IVF Procedure for Male Infertility Doubled</a>